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Semaglutide’s clinical efficacy profile , characterised by HbA1c reductions of 1.5–2.0% and body weight reductions of 10–15% with subcutaneous dosing and up to 17% with the higher-dose Wegovy formulation , represents the highest efficacy achieved by any selective GLP-1R agonist and substantially exceeds the outcomes achieved with liraglutide, exenatide, and earlier GLP-1R agonists